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BPC-157 is a synthetic derivative of the body protection compound (BPC), a protein found in the stomach. BPC is responsible for the protection of the stomach lining against damage, angiogenesis, and healing through tissue regeneration.
BPC-157, comprised of 15 amino acids, is suspected to retain the healing properties of its parent compounds. Furthermore, research concludes that it might mediate NO release, inhibit infammation and trigger the synthesis of growth factors. Researchers from all over the world are interested in exploring its medicinal properties, especially its healing capacity. On our website, BPC-17 for sale is available for scientific and research purposes.
Synonyms: BPC-15, Booly protection compound 15 Molecular Weight: 1419.5 g/molMolecular Formula: C62H98N16O22 Sequence: GEPPPGKPADDAGLV CAS number: 137525-51-0 PubChem CID: 108101
Numerous studies indicate that this man-made compound is involved in angiogenesis, the formation of new blood vessels. In a study, rats suffering from ischemic colitis treated with BPC-157 (10ug/kg) experienced quick restoration of blood supply in the ischemic area .
In another study conducted on rats, the inferior vena cava vein was ligated, which commonly results in a disturbance of blood flow, vessel injury and formation of thrombus. Subjects when treated with BPC-157 counteracted these effects and demonstrated redistribution of trapped blood volume .
Studies show that its angiogenic effect might be due to the stimulation of VEGFR2, which is a receptor present on the surface of cells that mediates the NO signaling pathway. In a study, increased expression of VEGFR2 was found after BPC-157 treatment in rats with hind limb ischemia that further activated the VEGFR2-Akt-eNOS pathway. On the contrary, administration of dynasore (inhibitor of VEGGR2) didn’t activate the pathway and blocked endothelial tube formation .
Research shows that BPC-157 is involved in the healing of wounds. In a study, the gastroprotective effect of body protection compound 157 was investigated in rats with acute or chronic gastric ulcer. BPC-157 administration via both the intranasal and intragastric routes accelerated ulcer healing and effectively reduced the size of the ulcer. Furthermore, it was observed that continuous BPC-157 treatment induced the rebuilding of glandular epithelium and glandular tissue formation .
In another study, intraperitoneal administration of BPC-157 (2ug/kg) improved motor function, reduced lesions in white and grey matter and relieved neuronal damage in rats with spinal cord injury 
Research in the alkali burn rat models has shown that topical BPC-157 can speed up wound closure. Moreover, it reveals that possible mechanisms behind this effect might include granulation tissue formation, reepithelialization and deposition of collagen through the ERK1/2 signaling pathway 
Research on animal models shows that BPC-157 has the potential to improve performance and recovery from injuries. In a study, BPC-157 was administered through either, intraperitoneal, oral or topical root after the surgical resection in rats. The results found improved healing of transected medial collateral ligament with the treatment, indicating that BPC-157 holds the potential for improving acute ligament injuries .
Another study aimed to investigate the possible mechanism by which BPC-157 speed up the healing of the injured tendon. The results showed that BPC-157 accelerated the outgrowth of tendon fibroblasts and it increased the survival of these cells under the H202 stress. It also enhanced the migration and spreading of tendon fibroblast in a dose-dependent manner. Moreover, increased expression of FAk and paxillin was observed, and it was speculated that these proteins might be involved in mediating the recovery of injured tendons .
BPC-157 was also found to be effective in accelerating the recovery from transected muscles and muscle-crushed injuries in rats. Plus, it has been shown to counteract the negative impact of corticosteroids in tendon-to-bone healing .
Various studies show that BPC-157 has a neuroprotective effect. Research conducted on rats showed that this synthetic peptide can counteract the effects of cuprizone, a drug that induces demyelination of nerve fibers and mimic the damage caused by multiple sclerosis, by reducing nerve damage .
In another study, intraperitoneal administration of BPC-157 alleviated the effects of MPTP by improving somatosensory orientation, reducing hyperactivity and decreasing motor abnormalities. MPTP is an agent used to mimic the damage caused by Parkinson’s disease 
Furthermore, BPC-157 was found to be effective in improving memory, locomotion and coordination and relieving neuronal damage in rats with stroke induced by bilateral clamping. These studies indicate that this synthetic analogue has the potential to treat several central nervous system disorders .
Tb-500 is a synthetic derivative of thymosin beta-4 (Tβ-4), a naturally occurring peptide present in Thymus gland. Research shows that BPC-157 and TB500 aid in the wound healing and may have synergistic effect when combined. As we discussed above, BPC-157 is involved in the growth and migration of fibroblasts . Fibroblasts play an important role in turnover of extracellular matrix. Following the injury, fibroblast become active and transform into myofibroblasts that aid in wound healing process by reducing the size of wound. Migration of fibroblast to area of injury is an important step in the recovery of wound that depends on actin protein . Research shows that Tb-500 is involved in sequestering actin molecules to form filaments that promote cell movement. Further, Tβ-4 is involved in angiogenesis, collagen deposition and inhibits apoptosis and inflammation, thus adding to the medicinal effect of BPC-157 .
Various studies on animal models confirmed the angiogenic effect and healing properties of BPC-157. It has the potential to speed up the recovery of musculoskeletal injuries but is not yet approved by the FDA for clinical use in humans. As an experimental drug, BPC-157 purchase is limited to educational and research institutions. Only buy BPC-157 if you are a licensed researcher.
All products on this site are for Research, Development use only. Products are Not for Human consumption of any kind.
The statements made within this website have not been evaluated by the US Food and Drug Administration. The statements and the products of this company are not intended to diagnose, treat, cure or prevent any disease.