Frag Premium 176-191 5MG

Frag Premium 176-191 5MG

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$49.99
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The Frag Premium 176-191 5MG for sale here are intended for laboratory and research use only, unless otherwise explicitly stated. They are not intended for human ingestion or for use in products that may be ingested.
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What Is Frag Premium 176-191 5MG?

Fragment 176-191, also known as AOD9604, is a synthetic peptide derived from fragment 176-191 at the C-terminus of human growth hormone. It is sometimes referred to as a lipolytic fragment of growth hormone as this part is associated with fat metabolism. Research shows that it lowers blood glucose levels without altering insulin sensitivity. It also stimulates lipolysis and inhibits lipogenesis.

The research involving frag 176-191 is limited. Studies show that it has a similar mechanism of action as AOD9604. AOD9604 is another fragment (177-191) of the human growth hormone that binds to GH receptors and produces a GH-like effect on the metabolism of cartilage without stimulating the proliferation of cells. It is available as a research chemical and is not approved by FDA. At Element Sarms, Fragment 176-191 for sale is exclusively available for qualified researchers.

Structure Of Frag Premium 176-191 5MG

structure

From Pubchem

Synonyms: 66004-57-7, Hgh (176-191), DTXSID10216216
Molecular Formula: C78H123N23O22S2
Molecular Weight: 1799.1 g/mol
CAS Number: 66004-57-7
PubChem CID: 16131230

Frag Premium 176-191 5MG Uses In Research

1. Frag 176-191 and Fat loss

Studies on animal models show that lipolytic fragments of the human growth hormone can induce fat-burning and weight loss. One study in obese Zucker rats was conducted to assess its lipolytic effect. The subjects were given AOD9604 of 500 microg/kg body weight or placebo for 19 days. The results found that the treatment group observed a 50% reduction in weight gain as compared to the control group. The data suggests that the lipolytic fragment of growth hormone might have the potential to be developed into a safe oral dose for obesity [1].

In another study, chronic administration of AOD9604 for 14 days reduced body weight and body fat in obese mice. Further, this synthetic fragment increased the repressed expression of beta-3 adrenergic receptors in obese mice to levels comparable to those found in lean mice. The activation of these receptors stimulates fat burning in adipose tissue and enhances thermogenesis in skeletal muscles. Mice with no gene for beta-3 adrenergic receptors didn’t experience changes in body composition or an increase in lipolysis [2].

2. Frag 176-191 and Diabetes

Research shows that the lipolytic fragment of human growth hormone might benefit diabetes. A study was conducted to examine the effect of fragments of growth hormone, involving frag 176-191, on glucose levels. The researchers found that out of all tested fragments, 176-191 was most effective for lowering blood sugar levels. This effect was secondary to an increase in the levels of plasma insulin and reduced insulin sensitivity [3].

3. Frag 176-191 and Cartilage Regeneration

Research indicates that the C- terminus peptide of human growth hormone might promote cartilage regeneration. One study investigated the effect of intra-articular injections of AOD906 with or without hyaluronic acid in a knee osteoarthritis rabbit model. Subjects were given either saline, hyaluronic acid, AOD9604 or AOD9604 with hyaluronic acid. The results indicated that AOD9604 enhanced cartilage regeneration and its combination with hyaluronic acid had an even more pronounced effect [4].

4. Summary

Frag 176-191 is a modified form of the human growth hormone fragment 176-191 at the C-terminus. Research shows that it might be able to induce fat and weight loss in obese persons, promote cartilage regeneration and benefit diabetic people. The current research on this topic is quite limited; however, there is significant potential for further exploration and investigation. It is a research molecule, which means you can only purchase fragment 176-191 for research. If you are wondering where to buy fragment 176-191, shop from Element Sarms to elevate your research.

Certificate of Analysis (COA)

COA

High Performance Liquid Chromatography (HPLC)

COA

Mass Spectrometry (MS)

COA

Growth Hormone peptide fragment 176-191, also known as HGH Frag 176-191, is a modified form of amino acids 176-191 of the GH polypeptide. Investigators at Monash University discovered that the fat-reducing effects of GH appear to be controlled by a small region near one end of the Growth Hormone molecule. This region, which consists of amino acids 176-191, is less than 10% of the total size of the GH molecule and appears to have no effect on growth or insulin resistance. It works by mimicking the way natural Growth Hormone regulates fat metabolism but without the adverse effects on blood sugar or growth that is seen with unmodified Growth Hormone. Like Growth Hormone, the hgH fragment 176-191 stimulates lipolysis (the breakdown or destruction of fat) and inhibits lipogenesis (the transformation of nonfat food materials into body fat) both in laboratory testing and in animals and humans. Laboratory Tests and Fat Loss In laboratory tests on fat cells from rodents, pigs, dogs, and humans, the hgH fragment released fat specifically from obese fat cells but not from lean ones, reduced new fat accumulation in all fat cells, enhanced the burning of fat. In rodents (rats and mice), hgH fragment reduced body fat in obese animals but, enhanced fat burning without changing food consumption or inducing growth (as it does not increase IGF levels) or any other unwanted Growth Hormone effect. Research dosages of 500mcg of the hgH fragment 176-191 daily for 30 days did show a reduction of body fat in the mid abdominal area in both obese, over-weight, and average built people. Fragment 176-191 as an Active HGH Truncated Peptide hgH fragment 176-191 is an analog of the growth hormone-releasing factor (GRF) which signals the effects of growth hormone. It is a 15-mer peptide residue of the C-terminus of HGH to which tyrosine is added at the N-terminal end. This synthetically produced hormone is very common to weightlifters and bodybuilders because of a number of physical benefits. Studies claimed that it actually acts on the reduction of excessive adipose tissues such as those in the abdominal area, increase in muscle mass, and enhances the lipid content of the body. These segments of the synthetic peptide hgH 176-191 have been investigated for their in vivo effects in laboratory mice musculus. Research results have shown that hgH 176-191 have resulted to a short-period increase in blood glucose and a more sustained increase in plasma insulin, together with other fragments such as 172-191, 177-191 and 178-191. In addition, the researchers have suggested that functionality of the peptide depends not only in the informational sequence but should also have the correct physical configuration (Ng and Borstein 1978). Also, this fragment, being a region of high accessibility to proteases and also rich in proline, have been demonstrated to affect the conformational change in the cytoplasmic domain of the band 3 of erythrocyte membrane protein by serving as the hinge for the pivoting of the two subdomains. This then suggest that such residue is significant in conformational changes be serving as sites for peripheral protein binding in some body cells (Low et al. 1984). In another study of Ng et al. (2000) on animal subjects, they found out that a 500mcg dosage of the said hormone increased the lipolytic activity in adipose tissues without having negative influence in the blood glucose level. Furthermore, though it behaves like a human growth hormone (hgH), it does not causes hyperglycemia because it does not compete with hgH receptors (Wu et al. 1993). Because of such effects, researchers have suggested that it might be used for the elimination of excess abdominal fat which is a significant aspect of HIV-associated lipodystrophy. The (hgH fragment 176-191) exhibits the ability to burn through stubborn adipose tissue, while increasing energy expenditure, muscle mass, and fat oxidation. All studies have pointed to the fact that the fragment is an effective treatment for obesity and fat loss, and much safer than its Human Growth Hormone counterpart.
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