Sermorelin is a synthetic peptide analog of growth hormone-releasing hormone (GHRH). It binds with GHRH receptors in the pituitary gland and triggers growth hormone release and production. Besides promoting growth, it has the additional benefit of reducing scarring following a heart attack, increasing bone density, improving renal function and reducing seizure activity.

IFDA approved Sermorelin in 1997 for the treatment of growth hormone deficiency in children. It was sold under the brand name Geref. Later, FDA withdrew its approval in 2008 because of commercial reasons. Currently, scientists are interested in exploring its effect on sleep, brain tumor and heart health. Right now, sermorelin for sale is available for research purposes only.

From Pubchem

Synonym: Sermorelina, 86168-78-7, Somatoliberin
Molecular Formula: C149H246N44O42S
Molecular Weight: 3357.9 g/mol
Sequence: YADAIFTNSYRKVLGQLSARKLLQDIMSR
CAS Number: 86168-78-7
PubChem CID: 16132413

1. Sermorelin and Growth Hormone Deficiency

Because of its growth hormone-releasing properties, it can be used in people with this hormone deficiency. In fact, it is preferred over the administration of synthetic growth hormone (GH). It mimics the process by which the human body naturally produces GH in an episodic and intermittent manner rather than constant levels achieved by injecting GH.

Also, sermorelin is subject to the negative feedback mechanism which involves somatostatin, an inhibitor of growth hormone, to prevent unwanted side effects associated with improper dosing. Further, it can avoid tachyphylaxis, loss of drug response after repeated or continued exposure, unlike exogenous GH administration [1].

2. Sermorelin and Antiaging

Levels of growth hormone and GHRH decline with advancing age. Sermorelin can be effectively used to treat growth hormone deficiency in adults. It stimulates the production of IGF-1 in the liver and increases pituitary preserve, thus preserving the hormone neuroendocrine axis and youthful physiology [1].

In a randomized single-blind placebo-controlled trial, participants involving elderly men and women self-injected placebo for 4 weeks followed by GHRH analog administration for sixteen weeks. GHRG analog administration at night resulted in an acute increase in growth hormone within 10 minutes that lasted for up to 2 hours. This effect was sustained during the course of the whole study. Further, researchers observed elevated IGF-1 and IGFBP3 levels, increased skin thickness and lean body mass. However, only men experienced improved insulin sensitivity and libido, suggesting that the treatment has a more pronounced effect on women than men [2].

3. Sermorelin and Cardiac Remodeling

Research shows that sermorelin can prevent cardiac remodeling and reduce scarring after myocardial infarction. In a study conducted on swine, twenty-five subjects (25 to 30kg) with ischemic cardiomyopathy induced by occlusion of the left descending coronary artery were randomized to either receive a placebo or GHRH analog. The result found that the administration of GHRH analog significantly reduced the size of the infarct and improved diastolic strain. Further, it was suggested that local activation of the GHRH pathway resulted in the repairing process [3].

4. Sermorelin and Sleep

IResearch shows that sleep loss might be related to cognitive decline associated with age. GHRH analog administration has been shown to improve sleep, which might stem from its beneficial effects on cognition [4].

Further, it was suggested that orexin is important for sleep cycle regulation. Studies indicate that the administration of GHRH analogs, sermorelin, can enhance orexin secretion [5].

5. Summary

Sermorelin was first approved for the treatment of growth hormone deficiency in children in 1997. But later, its sale was withheld. Currently, it has been researched for its effect on the treatment of sleep, myocardial infarction and age-related problems. We don’t support its unwarranted medical use and offer sermorelin purchase only for research and educational institutions. So if you are a researcher looking to explore its potential therapeutic use, buy sermorelin from Element Sarms.

1. Walker, R.F., Sermorelin: A better approach to management of adult-onset growth hormone insufficiency? Clinical Interventions in Aging, 2006. 1(4): p. 307-308.
2. Khorram, O., G.A. Laughlin, and S.S. Yen, Endocrine and metabolic effects of long-term administration of [Nle27]growth hormone-releasing hormone-(1-29)-NH2 in age-advanced men and women. J Clin Endocrinol Metab, 1997. 82(5): p. 1472-9.
3. Bagno, L.L., et al., Growth hormone-releasing hormone agonists reduce myocardial infarct scar in swine with subacute ischemic cardiomyopathy. J Am Heart Assoc, 2015. 4(4).
4. Benedict, C., C.D. Chapman, and H.B. Schiöth, Growth Hormone–Releasing Hormone Improves Cognitive Function in Older Adults: Sleep On It. JAMA Neurology, 2013. 70(4): p. 529-530.
5. BShepherd, B.S., et al., Endocrine and orexigenic actions of growth hormone secretagogues in rainbow trout (Oncorhynchus mykiss). Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2007. 146(3): p. 390-399.