Toremifene Citrate 60MG/ML | 30ML with dropper

Toremifene Citrate 60MG/ML | 30ML with dropper

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The Toremifene Citrate 60MG for sale here are intended for laboratory and research use only, unless otherwise explicitly stated. They are not intended for human ingestion or for use in products that may be ingested.
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What Is Toremifene Citrate 60MG/ML | 30ML with dropper?

Toremifene (TOR) is a second-generation selective estrogen receptor modulator (SERM) that is primarily used to treat hormone receptor-positive breast cancer in postmenopausal women. It binds to estrogen receptors in breast tissues and interferes with the growth and proliferation of cancer cells. It is a chlorinated derivative of tamoxifen (TAM) and is equally effective in treating breast cancer.

Toremifene was first approved by the FDA in 1997 for the first-line treatment of estrogen receptor-positive breast cancer or unknown metastatic cancer in postmenopausal women. It has also been shown to have effects on bone mineral density and lipid profiles. At Element Sarms, toremifene purchase is restricted to educational and research purposes.

Structure Of Toremifene Citrate 60MG/ML | 30ML with dropper

structure

From Pubchem

IUPAC Name:2-[4-[(Z)-4-chloro-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine
Synonyms: Acapodene, Farestone, Z-Toremifene
Molecular Formula: C26H28ClNO
Molecular Weight: 406.0 g/mol
CAS Number: 89778-26-7
PubChem CID: 3005573

Toremifene Citrate 60MG/ML | 30ML with dropper Uses In Research

1. Toremifene and Breast Cancer

Toremifene has been widely used to treat hormone receptor-positive breast cancer in both early and late stages. Its efficacy has been well established by nine prospective randomized phase III trials. The results of these studies show that toremifene has an equivalent efficacy to tamoxifen but has a slightly better side effect profile. TOR is less likely to cause vascular events and uterine neoplasms and has a better effect on serum lipid levels [1].

Furthermore, toremifene has a different pharmacokinetic profile as compared to tamoxifen. Tamoxifen is a prodrug that is converted into its active metabolites by CYP2D6 isoenzymes. However, Toremifene doesn’t require enzymatic conversion by CYP2D6 for its activity. Studies show that genetic polymorphism within CYP2D6 affects the interindividual response to tamoxifen and toremifene might be an adjuvant alternative endocrine therapy for patients with CYP2D6*10 mutant genotype [2].

2. Toremifene and Bone Health

Toremifene has been shown to increase bone mineral density and prevent fracture. In a randomized phase III trial, men with prostate cancer on androgen deprivation therapy were randomized to receive toremifene (80mg/day) or placebo. The results found that toremifene significantly increased bone mineral density of the hip and spine [3]. Another study found that it significantly reduced the risk of new vertebral fractures by 79.5% in men younger than 80 years. Plus, it decreased bone loss by 7% and increased bone mineral density at all sites [4].

Furthermore, one study compared the effects of tamoxifen and toremifene on bone biochemistry and bone mineral density in postmenopausal women. Participants were randomized to receive either 20mg tamoxifen or 40 mg toremifene for a year. The research found that tamoxifen had a significant impact on increasing bone mineral density while toremifene didn’t influence BMD in postmenopausal women [5].

3. Toremifene and Prostrate Cancer

Toremifene has been shown to prevent prostate cancer in men at high risk. In a double-blind phase IIB clinical trial. 514 patients with prostatic intraepithelial neoplasia were randomized to receive either 20mg, 40mg and 60mg tamoxifen or placebo for 12 months. Prostatic Intraepithelial Neoplasia is characterized by pathological changes in the cell lining of the prostate gland ducts that are considered precursors to prostate cancer. The results found that the treatment decreased the incidence of prostate cancer and had a tolerability profile as compared to placebo [6].

4. Toremifene and Dyslipidemia

Research shows that toremifene has a positive effect on lipid profile. Dyslipidemia is common in postmenopausal women, which predisposes them to cardiovascular diseases. A phase III randomized clinical trial conducted on postmenopausal women with breast cancer found that toremifene decreased low-density lipoprotein cholesterol and increased high lipoprotein cholesterol [7].

Furthermore, men on androgen deprivation therapy are at high risk of coronary artery disease and myocardial infarction. A treatment-related increase in lipid serum levels might contribute to a greater risk of CVD. A phase III clinical trial found that toremifene decreased low-density lipoprotein cholesterol, triglycerides, and total cholesterol and increased high-density lipoprotein cholesterol [8].

5. Summary

Toremifene is a chlorinated derivative of tamoxifen, a non-steroidal selective estrogen receptor modulator. It has been approved by the FDA for the treatment of breast cancer in postmenopausal women. It shows equivalent efficacy to tamoxifen and promising results in the treatment of prostate cancer and management of side effects related to androgen deprivation therapy. At Element Sarms, toremifene for sale is exclusively available for research and educational institutions. Only buy toremifene if you are a qualified researcher.

Referenced Citations

  1. Mustonen, M.V., S. Pyrhönen, and P.L. Kellokumpu-Lehtinen, Toremifene in the treatment of breast cancer. World J Clin Oncol, 2014. 5(3): p. 393-405.
  2. Li, X., et al., Toremifene, an Alternative Adjuvant Endocrine Therapy, Is Better than Tamoxifen in Breast Cancer Patients with CYP2D6*10 Mutant Genotypes. Cancer research and treatment, 2023.
  3. Smith, M.R., et al., Toremifene increases bone mineral density in men receiving androgen deprivation therapy for prostate cancer: interim analysis of a multicenter phase 3 clinical study. J Urol, 2008. 179(1): p. 152-5.
  4. Smith, M.R., et al., Toremifene Decreases Vertebral Fractures in Men Younger Than 80 Years Receiving Androgen Deprivation Therapy for Prostate Cancer. The Journal of Urology, 2011. 186(6): p. 2239-2244.
  5. Marttunen, M.B., P.i. Hietanen, A. Tiitinen, and O. Ylikorkala, Comparison of Effects of Tamoxifen and Toremifene on Bone Biochemistry and Bone Mineral Density in Postmenopausal Breast Cancer Patients. The Journal of Clinical Endocrinology & Metabolism, 1998. 83(4): p. 1158-1162.
  6. Price, D., et al., Toremifene for the Prevention of Prostate Cancer in Men With High Grade Prostatic Intraepithelial Neoplasia: Results of a Double-Blind, Placebo Controlled, Phase IIB Clinical Trial. The Journal of Urology, 2006. 176(3): p. 965-971.
  7. Tominaga, T., et al., Effects of Toremifene and Tamoxifen on Lipid Profiles in Post-menopausal Patients with Early Breast Cancer: Interim Results from a Japanese Phase III Trial. Japanese Journal of Clinical Oncology, 2010. 40(7): p. 627-633.
  8. Smith, M.R., et al., Toremifene improves lipid profiles in men receiving androgen-deprivation therapy for prostate cancer: interim analysis of a multicenter phase III study. J Clin Oncol, 2008. 26(11): p. 1824-9.
Toremifene Citrate, a selective estrogen receptor modulator (SERM), is gaining recognition for its potential applications in various research areas, including cancer research, endocrinology, and reproductive studies. Element Sarms is the premier destination to buy Toremifen Citrate for your research endeavors. Our high-quality Toremifen Citrate for sale is tailored to fuel your scientific curiosity and empower you to achieve remarkable breakthroughs in the realm of biomedical research. Our Toremifen Citrate product offers exceptional purity and precision, providing you with the necessary tools to unlock new insights and drive scientific advancements. When you buy Toremifen Citrate online from our store, you can trust that you are acquiring a genuine product of superior quality. With our Toremifen Citrate, you can embark on your research journey with confidence. We prioritize customer satisfaction and strive to deliver a seamless purchasing experience, enabling you to focus on your scientific investigations.Unleash the full potential of your research with our Toremifen Citrate. Visit our website and explore our user-friendly online store to buy Toremifen Citrate online effortlessly. Please note that Toremifen Citrate for sale here is strictly intended for laboratory and research purposes, unless otherwise explicitly stated. They are not intended for human ingestion or for use in products that may be ingested.
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