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Cardarine, also known as GW 501516 and endurobol, is a man-made agonist of a peroxisome proliferator-activated receptor (PPAR). PPARs are receptors present in the nucleus that play a part in gene regulation and are involved in various physiological processes, including inflammation and cell differentiation.
Cardarine was first developed in the 1990s with the collaboration of GlaxoSmithKline and Ligand Pharmaceuticals as a potential treatment for cardiovascular diseases and metabolic disorders. Later, researchers found that it can increase endurance and enhance physical performance. Cardarine is not yet approved by the FDA and is classified as a new investigational drug. That means you can buy GW 501516 for research purposes only.
IUPAC Name:2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acidSynonyms: Endurobol, GW 1516Molecular Formula: C21H18F3NO3S2Molecular Weight: 453.5 g/molCAS Number: 317318-70-0PubChem CID: 9803963
Cardarine has been known to improve blood lipid levels and enhance fat loss. Activation of peroxisome proliferator-activated receptor upregulates the expression of genes responsible for beta-oxidation and energy dissipation, leading to less accumulation of fatty acids. Clinical studies showed that PARPδ agonists, including cardarine, have been associated with a reduction in hepatic fats in overweight patients with hyperlipidemia .
In a randomized controlled trial, participants were randomized to receive either cardraine (2.5 or 10mg) or placebo for two weeks. Researchers measured lipoprotein levels and evaluated gene expression for lipid metabolism and fatty acid oxidation. The result found that patients who took cardarine experienced an increase in HDL (good fat) and a reduction in triglyceride levels as compared to placebo. Further, it upregulated the expression of CPT1 and CD36, in addition to a two-fold increase in ABCA1, suggesting increased utilization of peripheral fat .
GCardarine increases energy expenditure by enhancing the body’s ability to utilize fat. It has been thought that it might improve stamina and enhance sports performance. World Anti-Doping Agency (WADA) has prohibited cardraine due to its potential misuse by athletes as a performance enhancer.
In one study, mice treated with cardarine experienced enhanced exhaustive running performance . Currently, there are no human studies available that support its use as a performance enhancer.
Research shows that cardarine exerts beneficial effects on type 2 diabetes mellitus. It improves insulin sensitivity and glucose control which might be due to the activation of AMPK by PPARδ. AMPK is a glucose-sensing signal which activates in the presence of falling cellular energy.
In one study, researchers assessed the effect of cardraine on gestational diabetes in rats. Rats with GDM (gestational diabetes mellitus) were tested for fasting blood glucose, fasting insulin and insulin sensitivity index on days 3, 10 and 7 while glucose tolerance was performed on day 20th of gestation. Researchers found improved blood glucose and insulin levels, with less damage caused to pancreatic beta cells. Further, cardarine promoted the expression of GLUT2 in islet tissue, which is involved in the cellular uptake of glucose .
Moreover, research shows that PPARβ/δ agonist is associated with accelerated wound healing in diabetic patients. One study found that sustained GW 501516 delivery achieved by double-layer encapsulation improved wound closure through fibroblast activation and by reducing oxidative stress .
Research shows that cardarine has been associated with potential cancer-causing properties. In one study, researchers found that GW 501516 enhanced colitis-associated colorectal cancer in azoxymethane/dextran sodium sulfate-induced mice .
Cardarine has been investigated for the treatment of metabolic disorders and cardiovascular diseases. However, the clinical research was discontinued due to its potential to cause cancer. FDA classify GW 501516 as a new investigational drug and it hasn’t been approved yet.At Element Sarms, we offer GW 501516 for sale as a research drug. Only purchase GW 501516 if you are an authorized researcher.
GW 501516, also known as Cardarine, is a popular compound in research known for its potential benefits in enhancing endurance and metabolic function. It has garnered significant interest in studying lipid metabolism, improving exercise performance, and potential therapeutic applications. When you choose to buy GW 501516 online from us, you gain access to a reliable source for your research needs. Our products are sourced from trusted suppliers, ensuring quality, purity, and consistency. Experience the convenience of purchasing GW 501516 online from our user-friendly platform. We offer competitive prices, discreet packaging, and prompt shipping to support your research endeavors. Unleash the potential of GW 501516 in your studies. Buy GW 501516 online today from Element Sarms and explore new insights in metabolic and cardiovascular research. We are the leading online peptide suppliers. Not only do we guarantee delivery, but we also guarantee GW-501516 has a purity level of 99%. We will replace GW-501516 if you are not fully satisfied when you buy GW-501516. Note: GW 501516 for sale here is intended for research purpose only and not for human consumption.
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