Hexarelin 5MG

Hexarelin 5MG

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For this product you will need: BACTERIOSTATIC WATER For reconstitution.

The Hexarelin 5MG for sale here are intended for laboratory and research use only, unless otherwise explicitly stated. They are not intended for human ingestion or for use in products that may be ingested.
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What Is Hexarelin 5MG?

Hexarelin, also known as examorelin, is a synthetic analog of ghrelin. Ghrelin, a naturally occurring hormone produced by the stomach, binds with the growth hormone secretagogue receptor (GHS-R1a) in the hippocampus that stimulates growth hormone release. Further, it is involved in the regulation of body weight and protection of cardiomyocytes.

Hexarelin is composed of six amino acids and is closely related to GHRP-6. A team of researchers at Tulane medical school first synthesized it in 1989 in an attempt to develop a growth hormone that had no effect on insulin, glucagon and sex hormone. They found that this synthetic peptide didn’t cause desensitization and had a longer half-life. Since its discovery, it gained the attention of researchers for its cardioprotective effects. On our website, hexarelin for sale is available for educational and research purposes.

Structure Of Hexarelin 5MG


From Pubchem

IUPAC Name: L-histidyl-2-methyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide
Synonyms: Examorelin, Examorelin [INN]
Molecular Formula: C47H58N12O6
Molecular Weight: 887.0 g/mol
Sequence: HXAWFK
CAD Number: 140703-51-1
PubChem CID: 6918297

Hexarelin 5MG Uses In Research

1. Hexarelin and Weight Loss

As growth hormone influences metabolism and fat utilization, hexarelin might have an effect on weight loss. In one study, the effect of hexarelin on weight loss was examined in nonobese insulin-resistant MKR mice and their wild-type counterparts (FVB mice) over a period of 12 days. Researchers found that hexarelin treatment significantly improved glucose tolerance and reduced plasma and liver triglycerides in insulin-resistant mice.

Further, it was suggested that the enhanced metabolic effect might be due to the increased differentiation of adipocytes and improved metabolism of lipids by hexarelin [1]. This peptide might have the potential to treat lipid disorders associated with metabolic syndrome.

2. Hexarelin and Heart Health:

Research shows that hexarelin exerts beneficial effects on cardiovascular health, including prevention of heart attack and remodeling. In one study, hexarelin, either alone or in combination with a GHS-R antagonist, was administered to spontaneously hypertensive rats from age 5 weeks to 16 weeks. The results found that hexarelin reduced cardiac fibrosis by decreasing the deposition of myocardial collagen and hydroxyproline content. It also reduced the expression of collagen I and III. Further, it alleviated left ventricular hypertrophy, high blood pressure and left ventricular dysfunction. The study found that these effects were mediated by the activation of GHS-R receptor, as its inhibitor nullified the impact of hexarelin [2].

Another study assessed the cardioprotective effect of hexarelin on rats. The researchers labelled the rat cardiac membrane with radioactive hexarelin. They isolated a binding protein that was found to be similar to CD36, a protein expressed in cardiomyocytes and endothelial cells. Activation of CD36 by hexarelin resulted in increased coronary perfusion pressure in a dose-dependent manner. The effect was absent in mice that lack binding protein, suggesting that CD36 might be involved in causing coronary vasospasm in atherosclerosis and hypercholesterolemia [3].

Furthermore, one more study was conducted to explore the mechanisms involved in the cardioprotective effect of hexarelin. Heart failure caused by myocardial infarction was induced by permanent ligation of the coronary artery in rats. These rats either received a placebo or 100ug/kg hexarelin twice a day for 30 days. The result found that the treatment group showed improved contractile function, alleviation of oxidative stress, fibrosis and apoptosis and reduced histopathological damages. All these effects were achieved by the up-regulation of eNOS and an increase in serum NO concentrations, indicating eNOS as a potential target for therapy against heart failure [4].

Besides its protective effect on heart cells in myocardial infarction, it can shield the heart from the damaging effect of other disorders as well. A study found that hexarelin counteracted the negative changes in cell contraction, calcium transients, action potential duration, and potassium currents in a mouse model of diabetes. Moreover, it enhanced GHS receptor expression and antiapoptotic signals, indicating its cardioprotective function in diabetic rats [5].

3. Hexarelin and Muscle Preservation

Hexarelin has been studied for its role in the prevention of muscle loss. It stimulates the release of growth hormone that promotes protein synthesis, prevents muscle breakdown and causes cell differentiation and proliferation. Therefore, it’s not a surprise that it can preserve muscle mass.

In one study, cisplatin-induced cachexia (muscle loss) was introduced in rats under study. Rats were either given a placebo (control group) or hexarelin. The results found that the control group experienced mitochondrial dysfunction and muscle atrophy. On the other hand, the group that received the test drug exhibited resistance to muscle loss and strength. Further, it was speculated that improved mitochondrial function and reduced inflammatory processes by hexarelin contributed to this effect [6].

4. Current Status of Hexarelin

Research in animal models shows that it can prevent heart attack and myocardial remodelling. Further, it has the potential to aid weight loss. However, we need more research to confirm these effects on humans. FDA hasn’t yet approved it for clinical use. At Element Sarms, hexarelin purchase is available for educational and research institutions. Only buy hexarelin if you are a licensed researcher.

Certificate of Analysis (COA)


High Performance Liquid Chromatography (HPLC)


Hexarelin (Hexarelin Acetate) is a synthetic hexapeptide in the growth factor family which stimulates the release of growth hormone (GH) and does not interfere with the body's ability to produce its own GH. Structurally, Hexarelin (Hexarelin Acetate) is similar in structure to GHRP-6 but without the appetite increase because of its inability to drastically increase Ghrelin levels which is responsible for the increased appetite and quicker gastric emptying. Hexarelin is a synthetic growth hormone secretagogue made from six amino acids. It contains powerful growth hormone releasing properties in the human body. Hexarelin in studies over a certain period has shown that it reduces visceral fat. Hexarelin (Hexarelin Acetate) like other Growth Hormone Releasing Peptides is most effective synergistically when administered with GHRH such as Sermorelin or Modified GRF 1-29. The increase of circulating GH through Hexarelin use causes levels of Insulin-Like Growth Factor (IGF-1) to rise in the liver. IGF-1 is the prime cause of muscle growth in response to GH stimulation. Users of IGF-1 typically experience increased strength and muscle mass, as well as a very pronounced fat loss.
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