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Bremelanotide, also known as PT-141, is a synthetic analogue of Melanotan II, a man-made variant of naturally occurring hormone in the human body that stimulates melanogenesis. PT-141 non-selectively stimulates several melanocortin receptor subtypes, out of which MC4R is the most significant. These receptors are involved in the mediation of various physiological processes including sexual desire.
It is a 7 amino acid peptide that was first found in literature in 2003. Since then, its medicinal use, particularly sexual health, has been explored by different scientists and researchers. On our website, PT-141 for sale is available for research purposes only.
Synonyms: Bremelanotide, PT-141Molecular Formula: C50H68N14O10Molecular Weight: 1025.2 g/molCAD Number: 189691-06-3PubChem CID: 9941379
Studies show that the binding of melanocortin agonists to MC4R can improve sexual response. In a study, 342 men who previously didn’t respond to sildenafil were either given 10mg bremelanotide through the intranasal route or placebo 45 minutes prior to sexual activity. The results found that 33.5% of participants who took PT-141 achieved erection than those who took placebo (8.3%) .
In a phase I study, bremelanotide safety, tolerability and pharmacokinetic effects were evaluated in male and female participants. Participants were randomized to receive either 20mg PT-14 (nasal route) or placebo with or without ethanol. The results found that single doses of 20 mg intranasal BMT is safe and generally well-tolerated in women, with average peak ethanol concentrations exceeding 80 mg/dL . Another study, a phase II trial, found self-administered subcutaneous PT-141 to be effective and safe in premenopausal women with sexual dysfunction .
On 21 June 2019, FDA approved the use of PT-141 for hypoactive sexual desire disorder in postmenopausal women on the basis of two phase 3 clinical trials. In these studies, the efficacy and safety of 0.75mg bremelanotide SC was observed in women with hypoactive sexual desire disorder. Results demonstrated that women who took PT-141 noticed a reduction in sexual distress and experienced an increase in desire as compared to placebo. The common side effects observed for bremelanotide were nausea, vomiting and flushing .
Melanocortin receptors play an important role in the regulation of appetite. Data from 2 phase one studies support the weight loss effect of bremelanotide. In one study, postmenopausal women treated with Pt-141 experienced greater weight loss and a mean reduction in caloric intake (400 kcal/day) as compared to the placebo group. 2nd study also replicated similar results, indicating that women who took PT-141 twice a day experienced weight loss and a reduction in calorie intake .
Bremelanotide is a synthetic analogue of Melanotan II. It has been extensively researched for its use in treating sexual dysfunction. FDA has already approved its use in postmenopausal women. It might have the potential to help lose weight. But we need more studies to confirm the results. On our website, Pt-141 purchase is available for educational and research. Only buy Pt-141 if you are a licensed researcher.
If you are looking to buy PT-141 online for your research needs, Look no further than Element Sarms! We provide top-notch PT-141 for sale that is ideal scientific investigations and studies. At Element Sarms, we place a high value on product excellence, ensuring that the PT-141 you receive for your research is trustworthy and pure. You can rely on us to supply the PT-141 you require thanks to our simple online purchasing process and safe payment choices, which are supported by our dedication to quality and client happiness. Buy PT-141 right away so you don't lose out on this useful research tool.
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