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Yohimbine is a naturally occurring alkaloid first identified by American botanist R. Raymond Hamet in 1934 in several herbal species. Its main sources are the bark of an African evergreen tree called Pausinystalia Yohimbe and the Indian snakeroot Rauwolfia serpentina. It has a long history of traditional use in medicine and has also been investigated for its pharmacological effects.
Yohimbine blocks the action of alpha-2 adrenergic receptors at the presynaptic site and increases norepinephrine levels in the blood. It is also thought to influence serotonin and dopamine receptors. Furthermore, it promotes the release of nitric oxide that causes the dilation of blood vessels and increases blood flow to the penis. Research shows that it exhibits anticancer properties and can treat erectile and myocardial dysfunction. On our website, yohimbine for sale is exclusively available for research and educational purchases.
IUPAC Name:methyl (1S,15R,18S,19R,20S)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylateSynonym: Yohimbine, Quebrachin, QuebrachineMolecular Formula: C21H26N2O3Molecular Weight: 354.4 g/molCAS Number: 146-48-5PubChem CID: 8969
Yohimbine has been used for the treatment of erectile dysfunction for several decades. A dose escalation study found yohimbine to be safe and effective for men with medically controlled hypertension. Further, it revealed that a 10.8 mg dose of yohimbine thrice a day produced a 100% erectile response in responders as compared to non-responders. The effect was more significant in non-smokers and participants with less severe erectile dysfunction .
One study in rats proposed that yohimbine acts on the α1 and α2 adrenergic receptors at the spinal level to facilitate ejaculatory function . Yohimbine works by binding to pre and postsynaptic α2-receptors that increase the release of norepinephrine (NE). NE in turn stimulates adrenergic receptors in the epithelium to release nitric oxide, which raises intracellular levels of cGMP and cCMP, causing the relaxation of penile smooth muscles .
Yohimbine has been shown to promote weight loss. A study conducted on athletes found that yohimbine significantly decreased fat mass as compared to the placebo group .
Furthermore, one study compared the effect of yohimbine and guanfacine (partial alpha 2 agonist) in rats with diet-induced obesity. The results found both drugs to be effective in reducing adipose tissue fat and had a beneficial lipid profile. Further, both drugs showed an anorectic effect (appetite suppression) .
Lipopolysaccharides play an important role in the pathogenesis of sepsis and cause cardiac dysfunction. It is known to reduce left ventricular ejection fraction and cardiac output. Research shows that NE promotes LPS-induced TNF- α production in Kupfer cells through stimulation of α2 adrenergic receptors.
One study in LPS-challenged rats found that yohimbine can reverse lipopolysaccharide-induced reduction in left ventricular ejection fraction, stroke volume and cardiac output . Research shows that α2 adrenergic receptor blockage can relieve septic cardiomyopathy by increasing cardiac NE release and inhibiting endothelial activation .
Furthermore, one more study concludes that pretreatment with yohimbine, along with berberine, can prevent LPS-induced myocardial infarction by inhibiting myocardial apoptosis and nitric oxide production .
Platelet aggregation plays a crucial role in the development of acute coronary syndrome. A study found that α2 adrenergic receptors have a major role in precipitating the interactive effect of collagen and epinephrine. Plus, yohimbine showed a greater effect in inhibiting platelet aggregation than MRS2179 (antagonist of the P2Y1 receptor) .
Research shows that increased sympathetic activation and plasma catecholamines can lower the risk of cancer survival due to activated stress mechanisms. Epinephrine and norepinephrine promote biological processes that cause cancer cell proliferation and inhibit immune response. G-protein coupled receptors regulate proliferation and metastasis and are involved in various cancer types, including lungs, prostate, breast and ovarian.
Yohimbine has been shown to inhibit various GPCRs including α2B adrenergic receptors, dopamine D2B receptors, and hydroxytryptamine receptors. A recent study found that the ring-distorted yohimbine derivative, Y7, has an antagonist action at oxytocin (OXTR) and arginine vasopressin receptors (AVPR1A, AVPR1B, and AVPR2) that are thought to be involved in prostate and small lung cancer [10, 11].
Furthermore, one study in rats found that yohimbine significantly decreased the levels of dihydrotestosterone, prostate-specific antigen and steroid 5-α reductase. This data suggests that yohimbine has a beneficial effect against benign prostatic hyperplasia by modulating the steroid 5α-reductase pathway .
Yohimbine is a naturally occurring alkaloid present in various herbs, including Pausinystalia Yohimbe and Rauwolfia Serpentina. It is an alpha-2 adrenergic antagonist that has been shown to improve erectile and myocardial dysfunction. Further, research shows that it promotes weight loss and exhibits antitumor properties. However, well-designed clinical trials are recommended to evaluate its safety and efficacy in humans. At Element Sarms, yohimbine purchase is restricted to research and educational institutions. Only buy Yohimbine if you are a qualified researcher.
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