Cardarine, also known as GW-501516, is an agonist of the peroxisome proliferator-activated receptor (PPAR). Activation of this receptor boosts endurance and upregulates the expression of genes responsible for fat metabolism. Furthermore, it improves insulin sensitivity by targeting AMPK, a glucose-sensing signal that activates in the presence of low cellular energy.

S4 andarine is a nonsteroidal selective androgen receptor modulator. It is known to enhance physical strength and endurance and is prohibited by the World Anti-Doping Agency. Moreover, it has been shown to improve bone mineral density and prevent fractures. Element Sarms offers the option to buy GW-501516 and S4 andarine together in a stacked bundle.