TB-500 5MG

TB-500 5MG

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The TB-500 5MG for sale here are intended for laboratory and research use only, unless otherwise explicitly stated. They are not intended for human ingestion or for use in products that may be ingested.
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What Is TB-500 5MG?

Tb-500 is a man-made analogue of thymosin beta-4, a naturally occurring peptide produced by the thymus gland. Thymosin beta-4 is involved in the mediation of various biological processes, including cell differentiation, angiogenesis, tissue regeneration, wound healing and many other functions. It is made up of 43 amino acids and is present in different cells of the body including saliva, tears, wound fluid and blood. Most of the research points to the use of thymosin beta-4, a structurally similar compound to the TB-500, so synthetic TB-500 is expected to replicate similar results as Tβ4 [1].

Thymosin beta 4 was first isolated from the bovine thymus gland in the 1980s. After that, its synthetic version TB-500 was developed in 2010. Although being developed for veterinary purposes, people started using it in competitive horse racing, purposefully offering a distinct edge to treated horses. Consequently, its use got banned in horse racing and sports competitions. On our website, Tb-500 for sale is limited to educational and research purposes.

Structure Of TB-500 5MG

structure

From Pubchem

Synonyms: QHK6Z47GTG, TB-500
Molecular Formula: C38H68N10O14
Molecular Weight: 889.0 g/mol
Sequence: LKKTETQ
CAD Number: 885340-08-9
PubChem CID: 62707662

TB-500 5MG Uses In Research

1. TB-500 and Angiogenesis

TB-500 is known to be involved in the formation of new blood vessels; a process known as neovascularization. One research identifies Tβ4 as essential for the development of coronary vessels in mice. Further, the experiment reveals that the test compound triggers the growth of previously inactive epicardial explants and the differentiation of fibroblasts, muscle cells and endothelial cells [2].

A study was conducted to assess the mechanism behind the angiogenic effect of Tβ4. The test tubes containing endothelial cells were treated with Tβ4, along with inhibition of AKT and PI3Kα/Rho pathway. Further, in vivo studies using animal models (mice and rabbit) were done by injecting Tβ4 either along with the application of rAAV.AKT-dn or inhibition of Rho/PI3K/AKT pathways. Kindly note that AKT is a kinase protein crucial for the PI3/AKT pathway, and AKT-dn is a negative dominant form of AKT that disturbs its normal function. The results of this study found reduced formation of blood vessels with the inhibition of the PI3/AKT pathway, indicating its importance in mediating angiogenesis [3].

2. TB-500 and Muscular Dystrophy:

In a study, dystrophin-deficient mice, the mouse model of Duchenne muscular dystrophy, was treated with Tβ4 twice a week for six months. Results found an increased number of muscle-regenerating fibers in mice treated with Tβ4 as compared to untreated ones, indicating the potential of Tb-4 as an effective therapy for muscular dystrophy [4]. Furthermore, thymosin beta-4 promotes the survival of cardiomyocytes and repairs damage to the heart [5].

3. Tb-500 and Recovery from Injury:

Various studies on animal models found that thymosin beta-4 can aid in wound healing and speed up recovery from injuries. One study in rats found Tb-4 to be effective in treating incisional wounds with minimal scarring. Moreover, it revealed that wounds treated with the peptide were narrow in width, had more organized collagen fibers and displayed red birefringence (an indication of mature connective tissues). While the untreated wounds displayed green birefringence, indicative of immature connective tissues, and had disorganized collagen fibers [6].

In a study, Tβ4 treatment six hours after traumatic brain injury lessened the size of cortical lesions and improved functional recovery in rats. While delayed treatment (24 hours after injury) didn’t alter the size of cortical lesions but significantly affected functional recovery in rats [7].

In a randomized double-blind, placebo-controlled, dose-escalation phase II trial, topical administration of Tβ4 improved wound healing in patients with venous ulcers. Furthermore, it found that a 0.03% dose of synthetic thymosin beta-4 helped 25% of the patients achieve full recovery whose wound size was small to moderate [8].

Thymosin beta 4 is believed to improve the recovery of injured tissues through its actin-sequestering properties. In the site of injury, thymosin B-4 binds with actin that promotes migration and differentiation of stem cells, resulting in the formation of new vessels that aid in wound healing. Further, it causes decreases in the number of myofibroblasts at the site of injury, thus reducing scar formation [9].

4. Thymosin Beta 4 and Dry Eyes.

Thymosin beta-4 might be involved in the healing of the corneal surface. A study conducted on 72 subjects found 0.1% Tβ4 as an effective treatment for relieving symptoms of dry eyes with no adverse effects being reported [10].

In another study, nine patients with severe dry eyes were given Tβ4 eye drops or placebo six times per day for 28 days. Participants treated with the drug experienced a 35.3% reduction of ocular discomfort, 59.1% reduction of total corneal fluorescein staining and increased tear production as compared to those who received a placebo [11].

5. Current status of Tb-500

Various studies on animal models speak for the beneficial effect of Tb-4 in wound healing and angiogenesis. It hasn't been yet approved by the FDA for clinical use in humans. More research is needed to confirm the medicinal effects of TB-500 in humans. As an experimental drug, TB-500 purchase is limited for research, only buy Tb-500 if you are a licensed researcher.

Referenced Citations

  1. Ho, E.N.M., et al., Doping control analysis of TB-500, a synthetic version of an active region of thymosin β4, in equine urine and plasma by liquid chromatography–mass spectrometry. Journal of Chromatography A, 2012. 1265: p. 57-69.
  2. Smart, N., et al., Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization. Nature, 2007. 445(7124): p. 177-82.
  3. Trenkwalder, T., et al., Thymosin-β4-mediated therapeutic neovascularization: role of the PI3K/AKT pathway. Expert Opin Biol Ther, 2015. 15 Suppl 1: p. S175-85.
  4. Spurney, C.F., et al., Evaluation of skeletal and cardiac muscle function after chronic administration of thymosin beta-4 in the dystrophin deficient mouse. PLoS One, 2010. 5(1): p. e8976.
  5. Bjørklund, G., M. Dadar, J. Aaseth, and S. Chirumbolo, Thymosin β4: A Multi-Faceted Tissue Repair Stimulating Protein in Heart Injury. Curr Med Chem, 2020. 27(37): p. 6294-6305.
  6. Ehrlich, H.P. and S.W. Hazard, 3rd, Thymosin beta4 enhances repair by organizing connective tissue and preventing the appearance of myofibroblasts. Ann N Y Acad Sci, 2010. 1194: p. 118-24.
  7. Xiong, Y., et al., Neuroprotective and neurorestorative effects of thymosin β4 treatment following experimental traumatic brain injury. Ann N Y Acad Sci, 2012. 1270: p. 51-8.
  8. Guarnera, G., A. DeRosa, and R. Camerini, The effect of thymosin treatment of venous ulcers. Ann N Y Acad Sci, 2010. 1194: p. 207-12.
  9. Goldstein, A.L., E. Hannappel, G. Sosne, and H.K. Kleinman, Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications. Expert Opin Biol Ther, 2012. 12(1): p. 37-51.
  10. Sosne, G., et al., Thymosin Beta 4 Eye Drops Significantly Improve Signs and Symptoms of Severe Dry Eye in a Physician-Sponsored Phase 2 Clinical Trial. Investigative Ophthalmology & Visual Science, 2013. 54(15): p. 6033-6033.
  11. Sosne, G. and G.W. Ousler, Thymosin beta 4 ophthalmic solution for dry eye: a randomized, placebo-controlled, Phase II clinical trial conducted using the controlled adverse environment (CAE™) model. Clin Ophthalmol, 2015. 9: p. 877-84.

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Mass Spectrometry (MS)

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TB-500 is a synthetic version of the naturally occurring peptide present in virtually all human and animal cells, Thymosin Beta-4. This potent peptide is a member of a ubiquitous family of 16 related molecules with a high conservation of sequence and localization in most tissues and circulating cells in the body. TB-500 not only binds to actin, but also blocks actin polymerization and is the actin-sequestering molecule in eukaryotic cells. TB-500 was identified as a gene that was up-regulated four-to-six fold during early blood vessel formation and found to promote the growth of new blood cells from the existing vessels. This peptide is present in wound fluid and when administered subcutaneously, it promotes wound healing, muscle building and speeds up recovery time of muscles fibres and their cells. An additional key factor of TB-500 is that it promotes cell migration through a specific interaction with actin in the cell cytoskeleton. It has been demonstrated that a central small amino acid long-actin binding domain has both blood cell reproduction and wound healing characteristics. These characteristics are uncovered by accelerating the migration of endothelial cells and keratinocytes. It also increases the production of extracellular matrix-degrading enzymes. Studies demonstrate that TB-500 is a potent, naturally occurring wound repair factor with anti-inflammatory properties. Tß4 is different from other repair factors, such as growth factors, in that it promotes endothelial and keratinocyte migration. It also does not bind to the extracellular matrix and has a very low molecular weight meaning it can travel relatively long distances through tissues. One of TB-500 key mechanisms of action is its ability to regulate the cell-building protein, Actin, a vital component of cell structure and movement. Of the thousands of proteins present in cells, actin represents up to 10% of the total proteins which therefore plays a major role in the genetic makeup of the cell. If you are looking to buy Tb-500 online for your research, then Element Sarms is the most trusted platform. By purchasing Tb 500 online, you gain access to a high-quality research-grade compound that is carefully manufactured for purity and consistency. Explore the diverse applications of Tb 500 in your research projects and unlock new possibilities for advancing the field of regenerative medicine. Buy Tb 500 today and accelerate your research journey towards groundbreaking discoveries. Note: TB-500 for sale here is intended for laboratory and research use only, unless otherwise explicitly stated. This product is not intended for human ingestion or for use in products that may be ingested.
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