GHK-CU Copper Peptide 50MG

GHK-Cu, also known as copper peptide, is a copper complex of tripeptide containing glycine, histidine and lysine. It is naturally found in human plasma, saliva and urine, and its level decline as we age. It is involved in the regulation of various body processes, including wound healing, formation of blood vessels, protein synthesis, collagen production and tissue regeneration.

It was first isolated from plasma albumin by Loren Pickart in 1973. Later research showed its role in tissue regeneration and wound healing. Since its discovery, it gained the attention of the cosmetic industry and scientists for its wound healing and anti-aging effects. FDA hasn’t yet approved it. On our website, GHK-Cu for sale is available for research and educational purposes.

From Pubchem

IUPAC Name: 6-amino-2-[[2-[(2-aminoacetyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoic acid;copper
Synonyms: SCHEMBL2243002, [Lysine, glycylhistidyl-, monocopper salt]
Molecular Weight: 403.92 g/mol
Molecular Formula: C14H24CuN6O4
Sequence: GEPPPGKPADDAGLV
PubChem CID: 342538

1. GHK-Cu and Skin Health

GHK-Cu is widely used in cosmetics and skincare products. GHK-Cu is believed to tighten loose skin, reduce the appearance of fine lines and wrinkles, relieve photodamage and hyperpigmentation, and increase the proliferation of keratinocytes. It also enhances the synthesis of collagen, elastin and glycosaminoglycan [1].

One study conducted on women with symptoms of photoaging found that GHK-Cu eye cream minimized the visible signs of aging after 12 weeks. Increased skin density and thickness, reduced fine lines and wrinkles, and improved skin clarity were observed in women treated with GHK-Cu as compared to placebo [2].

Furthermore, it accelerates the healing of skin wounds. In a study, the effect of GHK-Cu containing liposomes was examined on human umbilical vein endothelial cells (HUVECs) proliferation and scald wound healing in mice. The treatment enhanced the growth of HUVECs by 33.1%. Furthermore, it increased the expression of cell cycle-related proteins (CDK4 and CyclinD1), vascular endothelial growth factor and fibroblast growth factor 2, indicating enhanced tissue repair and growth. GHK-cu-treated mice observed improved angiogenesis and the wound healing was shortened (14 days) as compared to the untreated mice group [3].

Excessive inflammation makes wounds take longer time to heal and leave scars. GHK-Cu decreased the secretion of IL-16 induced by TNF-alpha in skin fibroblasts. IL-16 is a proinflammatory cytokine involved in skin inflammation. Because of its inflammatory properties, it has been suggested to use GHK-Cu topically instead of corticosteroids [4].

2. GHK-Cu and Hair Growth

GHK-Cu has a positive effect on hair growth and thickness. As it stimulates angiogenesis, the formation of new blood vessels can make nutrients and oxygen more accessible to hair follicles, thus preventing them from shrinking. One study investigated the safety and efficacy of 5-aminolevulinic acid (5-ALA) and glycyl-histidyl-lysine (GHK) for pattern hair loss. It included 45 male participants with pattern hair loss who either received the test drug (100mg/ml or 50mg/5) or placebo once a day for six months. Increased hair count was observed in the men taking the highest dose (100mg/ml), followed by males taking 50mg/ml drug and placebo [5].

3. GHk-Cu and Pain Management

One study found that GHK-Cu impacts pain-induced aggressive-defensive behaviour in a dose-dependent manner. The effect is thought to be mediated by L-lysine, as a similar effect was observed with the administration of L-lysine at doses similar to its amount in tripeptide [6].

4. GHK-Cu and DNA Repair

Recent evidence shows that GHK-Cu can rest the genes associated with diseased states in patients with cancer or COPD to a normal state. In COPD patients, this copper peptide suppresses destructive genes and stimulates remodelling activities while it reset genes associated with programmed cell death in cancer.

GHK affect the gene expression of almost 32.1% of human genes. The ability of a GHK-Cu to rest the genes might be useful for correcting diseased genes in elderly patients and might act as a preventive therapy for diseases like cancer, Alzheimer’s disease, COPD and nephropathy [7].

5. GHK-Cu and Nervous System

Neurodegeneration and cognitive decline are associated with advancing age. GHk-Cu can counteract the problems linked with age decline through angiogenesis, suppressing inflammation and resetting diseased genes [8]. In a study, rats pretreated with GHK were examined for water content, apoptosis and intact neurons after intracerebral hemorrhage. Results found GHK-Cu to be associated with less brain damage, reduced neuronal loss and improved function.

Furthermore, it prevented apoptosis and reduced the expression of microRNA (miR-339-5p) that is involved in programmed cell death. It also speculated that the p38 MAPK pathway might be involved in the downregulation of microRNA (miR-339-5p) [9].

6. GHK-Cu and Anxiety

One study found that intraperitoneal administration of GHk-Cu before the elevated maze test decreased anxiety in rats. The anxiolytic effect was apparent as rats spend more time in open arms rather than closed arms. Furthermore, the effect was more pronounced in rats who were administered the lowest dose (0.5 μg/kg) and it decreased with the increase in dose [10].

Summary

GHK-Cu is a naturally occurring copper complex of tripeptide found in plasma, saliva and urine. It is involved in the regulation of various body processes, including angiogenesis, collagen production and tissue regeneration. Its anti-aging effects make it a subject of interest for different scientists and researchers. At Element Sarms, GHK-Cu purchase is limited to educational and research purposes. Only buy GHK-Cu if you are a licensed researcher.

1. Pickart, L., J.M. Vasquez-Soltero, and A. Margolina, GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. Biomed Res Int, 2015. 2015: p. 648108.
2. Pickart, L., J.M. Vasquez-Soltero, and A. Margolina, GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. BioMed Research International, 2015. 2015: p. 648108.
3. Wang, X., et al., GHK-Cu-liposomes accelerate scald wound healing in mice by promoting cell proliferation and angiogenesis. Wound Repair Regen, 2017. 25(2): p. 270-278.
4. Gruchlik, A., M. Jurzak, E. Chodurek, and Z. Dzierzewicz, Effect of Gly-Gly-His, Gly-His-Lys and their copper complexes on TNF-alpha-dependent IL-6 secretion in normal human dermal fibroblasts. Acta Pol Pharm, 2012. 69(6): p. 1303-6.
5. Lee, W.J., et al., Efficacy of a Complex of 5-Aminolevulinic Acid and Glycyl-Histidyl-Lysine Peptide on Hair Growth. Ann Dermatol, 2016. 28(4): p. 438-43.
6. Sever’yanova, L.А. and M.E. Dolgintsev, Effects of Tripeptide Gly-His-Lys in Pain-Induced Aggressive-Defensive Behavior in Rats. Bulletin of Experimental Biology and Medicine, 2017. 164(2): p. 140-143.
7. Pickart, L., J.M. Vasquez-Soltero, and A. Margolina, GHK and DNA: Resetting the Human Genome to Health. BioMed Research International, 2014. 2014: p. 151479.
8. Pickart, L., J.M. Vasquez-Soltero, and A. Margolina, The Effect of the Human Peptide GHK on Gene Expression Relevant to Nervous System Function and Cognitive Decline. Brain Sci, 2017. 7(2).
9. Zhang, H., Y. Wang, and Z. He, Glycine-Histidine-Lysine (GHK) Alleviates Neuronal Apoptosis Due to Intracerebral Hemorrhage via the miR-339-5p/VEGFA Pathway. Front Neurosci, 2018. 12: p. 644.
10. Bobyntsev, II, et al., Anxiolytic effects of Gly-His-Lys peptide and its analogs. Bull Exp Biol Med, 2015. 158(6): p. 726-8.