LiquiTamo 20MG/ML | 30ML with dropper

LiquiTamo 20MG/ML | 30ML with dropper

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The LiquiTamo 20MG for sale here are intended for laboratory and research use only, unless otherwise explicitly stated. They are not intended for human ingestion or for use in products that may be ingested.
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What Is LiquiTamo 20MG/ML | 30ML with dropper?

Tamoxifen is a selective estrogen receptor modulator (SERM) that exhibits both estrogenic activity and antagonist effects. It binds to estrogen receptor in the breast tissues, blocks its action, and prevents the proliferation and growth of hormone-receptor-positive breast cancer. On the contrary, tamoxifen increases the activity of estrogen in bone, liver and uterine tissues. Furthermore, it is a potent activator of heat shock protein 90 (hsp90) and increases the Hsp90 molecular chaperone ATPase activity.

Tamoxifen was first synthesized by chemist Dora Richardson in 1962. FDA first approved it for the treatment of metastatic estrogen receptor-positive breast cancer in 1978. Later, it was approved for the prevention of breast cancer in women at high risk in 1998. It is also being studied for several other types of cancer and infertility. At Element Sarms, liquid tamoxifen purchase is restricted to research and educational purposes.

Structure Of LiquiTamo 20MG/ML | 30ML with dropper


From Pubchem

IUPAC Name:2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine
Synonyms: trans-Tamoxifen, Crisafeno, Diemon
Molecular Formula: C26H29NO
Molecular Weight: 371.5 g/mol
CAS Number: 10540-29-1
PubChem CID: 2733526

LiquiTamo 20MG/ML | 30ML with dropper Uses In Research

1. Tamoxifen and Breast Cancer

Tamoxifen has been widely used to treat and prevent breast cancer in women at high risk. It is either used alone or as an adjuvant in these treatments. However, it's no longer the preferred drug for cancer treatment as patients generally have better survival and compliance with anastrozole.

Furthermore, many patients develop resistance to tamoxifen as demonstrated by recurrence or progression on therapy. One of the major mechanisms for this phenomenon is the downregulation of estrogen receptors alpha (ERα). Moreover, studies show that excessive activation of the PI3/Akt pathway by inhibition of PTEN can induce tamoxifen resistance. PTEN, also known as phosphate and Tensin Homolog, is a tumor suppressor gene that downregulates the PI3/Akt signaling pathway.

One study found that there is a specific CAF (cancer-associated fibroblasts) subset in the breast cancer microenvironment known as CD63+ CAFs. It promotes tamoxifen resistance in breast cancer by secreting exosomes rich in miRNA, which binds to PTEN and ERα and inhibits their action. On the contrary, the pharmacological blockers of CD63+ CAFs boost the therapeutic effect of tamoxifen in breast cancer [1].

2. Tamoxifen and Infertility

Tamoxifen has been shown to have a positive impact on fertility. A study was conducted to check the effectiveness of tamoxifen in women with anovulatory (no ovulation) infertility. 160 women were recruited in the study and they received either 40mg or 80mg of tamoxifen. The results found that the women who took 40 mg had a pregnancy rate of 14.38% and those who were on 80mg had a pregnancy rate of 33.68%. Additionally, 35 out of 90 women with polycystic ovary syndrome (PCOS) had a 38.8% pregnancy rate, and 20 out of 70 women with clomiphene citrate failure achieved a 28.5% pregnancy rate. These findings suggest tamoxifen is a good alternative for clomiphene-resistant cases [2].

Furthermore, tamoxifen also exerts beneficial effects on sperm density. One study was conducted to evaluate the effect of tamoxifen on sperm density, motility and morphology. Participants were randomized to receive 10mg tamoxifen or placebo twice a day for three months. The results found improved sperm density and decreased dead spermatozoa in the treatment group as compared to the control group [3].

3. Tamoxifen and Gynecomastia

Gynecomastia, characterized by the enlargement of male breast tissues, is caused by an imbalancement of hormones, estrogen and progesterone. Tamoxifen has been used in the treatment of gynecomastia for several decades. A 10-year cohort concluded that 9 out of 10 men treated with tamoxifen experienced improvement in their symptoms [4].

Tamoxifen is found to be safe and effective for pubertal gynecomastia. Research recommends continuing treatment for at least 6 months and starting tamoxifen when the disc diameter is ≥3 cm to achieve the best result [5].

4. Tamoxifen and Myotubular Myopathy

Myotubular myopathy, also known as X-linked myotubular myopathy (XLMTM), is a severe congenital disorder caused by mutations in the myotubularin gene. It causes generalized hypertonia and muscular weakness, leading to neonatal death. Studies on animal models show that tamoxifen can ameliorate histological and pathological abnormalities related to MTM. Furthermore, it significantly prolongs life, boosts overall motor function, hinders disease progression, and prevents lower limb paralysis [6].

5. Current Status of Tamoxifen

Tamoxifen is a nonsteroidal selective estrogen receptor modulator. FDA has approved it for the treatment and prevention of breast cancer in women at high risk. At present, researchers are looking to explore its effect on XLMTM and fertility preservation in estrogen-sensitive tumor trial. At Element Sarms, liquid tamoxifen for sale is restricted to research and educational purposes. Only buy tamoxifen if you are a qualified researcher.

The selective oestrogen receptor modulator (SERM) tamoxifen is well known for its many research applications.It has been extensively studied and utilized in various fields, including cancer research, developmental biology, and reproductive studies. Our tamoxifen product ensures exceptional purity, enabling precise and reproducible results in your experiments. When you buy tamoxifen online from our store, you can expect a seamless purchasing experience. Rest assured that you will receive a reliable product that meets the highest industry standards. With our tamoxifen for sale, you can maximise the possibilities of your research. Visit our website to learn more about our user-friendly online store and to easily buy tamoxifen online with a few simple clicks. Note: Tamoxifen/LiquiTamo 20MG/ML for sale is strictly intended for laboratory and research purposes. It should not be used for human consumption or self-medication. Please ensure compliance with ethical guidelines and regulatory requirements governing the use of tamoxifen in your specific research area.
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